Authors: | Doungsoongnuen, Sutanun Pingaew, Ratchanok Prachayasittikul, Supaluk Prachayasittikul, Virapong Ruchirawat, Somsak Suksrichavalit, Thummaruk Worachartcheewan, Apilak |
Title: | Investigation on biological activities of anthranilic acid sulfonamide analogs |
Language (ISO): | en |
Abstract: | In the previous studies, the cytotoxicities of anthranilate sulfonamides were investigated. Herein, the bioactivities of 4-substituted (X = NO2, OCH3, CH3, Cl) benzenesulfonamides of anthranilic acid (5-8) are reported. The results revealed that all sulfonamides selectively exerted antifungal activity (25-50 % inhibition) against C. albicans at 4 μg/mL. Furthermore, compounds 6 and 8 show antioxidative (SOD) activity. These sulfonamides, except for 6, selectively display cytotoxic effects toward MOLT-3 cells. It is interesting to note that sulfonamides with electron withdrawing substituent (5, X = NO2) exhibited the highest cytotoxicity. This study provided preliminary structure-activity relationship of the anthranilic sulfonamides that is useful for further in-depth investigation. |
Subject Headings: | anthranilic acid antimicrobials antioxidants cytotoxicity sulfonamides |
URI: | http://hdl.handle.net/2003/29203 http://dx.doi.org/10.17877/DE290R-3249 |
Issue Date: | 2011-12-02 |
Appears in Collections: | Original Articles |
Files in This Item:
File | Description | Size | Format | |
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Prachayasittikul_071011_proof.pdf | DNB | 154.26 kB | Adobe PDF | View/Open |
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