Authors: | Kim, Min-Jin Yang, Kyong-Wol Kim, Sang Suk Park, Suk Man Park, Kyung Jin Kim, Kwang Sik Choi, Young Hun Cho, Kwang Keun Lee, Nam Ho Hyun, Chang-Gu |
Title: | Chemical composition and anti-inflammatory effects of essential oil from Hallabong flower |
Language (ISO): | en |
Abstract: | A number of essential oils derived from plants are claimed to have several medicinal functions, including anti-cancer and anti-inflammation effects. However, the chemical composition and biological activities of flower-derived components have not been sufficiently characterized. Therefore, we investigated the composition of essential oils from Hallabong flower [(Citrus unshiu Marcov × Citrus sinensis Osbeck) × Citrus reticulata Blanco] and their anti-inflammatory effects. Hydro-dist illed essential oils (HEOs) were analyzed using gas chromatography–mass spectrometry (GC–MS). In total, 21 components were identified, representing more than 98 % of the oils, with sabinene (34.75 %), linalool (14.77 %), β-ocimene (11.07 %), 4-terpineol (9.63 %), L-limonene (5.88 %), and γ-terpinene (4.67 %) as the main components. In the present study, we also investigated the anti-inflammatory effects of HEOs on lipopolysaccharide (LPS)-stimulated RAW 26 4.7 macrophage cells. HEOs were found to inhibit nitric oxide (NO) and prostaglandin E2 (PGE2) production and to suppress the LPS- induced expression of cyclooxygenase-2 (COX-2) protein. In addition, HEOs downregulated the production of the inflammatory cytokines, tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1 β(IC50 values are 0.05 %, 0.02 %, and 0.01 %, respectively). On the basis of these results, we suggest that HEOs can be consid ered potential anti-inflammatory candidates for therapeutic use in humans. |
Subject Headings: | chemical composition citrus flower essential oil inflammation Hallabong |
URI: | http://hdl.handle.net/2003/32970 http://dx.doi.org/10.17877/DE290R-7370 |
Issue Date: | 2013-11-07 |
Appears in Collections: | Original Articles |
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Hyun_07112013_proof.pdf | DNB | 450.9 kB | Adobe PDF | View/Open |
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