Authors: | Ham, Young Min Yoon, Weon-Jong Lee, Wook Jae Kim, Sang-Cheol Baik, Jong Seok Kim, Jin Hwa Lee, Geun Soo Lee, Nam Ho Hyun, Chang-Gu |
Title: | Anti-inflammatory effects of isoketocharbroic acid from brown alga, Sargassum micracanthum |
Language (ISO): | en |
Abstract: | During our on-going screening program designed to isolate natural compounds from marine environments, we isolated isoketochabrolic acid (IKCA) from Sargassum micracanthum, an important brown algae distributed in Jeju Island, Korea. Furthermore, we evaluated the inhibitory effects of IKCA on nitric oxide (NO) production in lipopolysaccharide (LPS)-triggered macrophages. IKCA strongly inhibited NO production, with an IC50 value of 58.31 μM. Subsequent studies demonstrated that IKCA potently and concentration-dependently reduced prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, and IL-6 cytokine production. In conclusion, to the best of our knowledge, this is the first study to show that IKCA isolated from S. micracanthum has a potent anti-inflammatory activity. Therefore, IKCA might be useful as an anti-inflammatory health supplement or functional cosmetics. |
Subject Headings: | brown alga inflammation isoketochabrolic acid Sargassum micracanthum |
URI: | http://hdl.handle.net/2003/35054 http://dx.doi.org/10.17877/DE290R-17102 |
Issue Date: | 2015-10-15 |
Rights link: | http://creativecommons.org/licenses/by/4.0/ |
Appears in Collections: | Original Articles |
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